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Adverse effect of repeated treatment with 5-aminoleveuic acid in healthy cats and those with chronic kidney disease.

Reo Nishi, et al.
Proinflammatory effects of oxidative stress in chronic kidney disease: role of additional angiotensin II blockade.  Agarwal R.
Oxidative stress is progressively enhanced with advancing stages of CKD. Dounousi E, Papavasiliou E, Makedou A, et al.
Transcription Factor Nrf2 Hyperactivation in Early-Phase Renal Ischemia-Reperfusion Injury Prevents Tubular Damage Progression Nezu M, Souma T, Yu L. et al.
5-ALA/SFC enhances HO-1 expression through the MAPK/Nrf2 antioxidant pathway and attenuates murine tubular epithelial cell apoptosis. Liu C, Fujino M, Zhu S, Isaka Y, et al.
5-Aminolevulinic acid exerts renoprotective effect via Nrf2 activation in murine rhabdomyolysis-induced acute kidney injury. Uchida A, Kidokoro K, Sogawa Y, et al.
Survival of cats with naturally occurring chronic renal failure is related to severity of proteinuria. Syme HM, Markwell PJ, Pfeiffer D, et al.
Histomorphometry of feline chronic kidney disease and correlation with markers of renal dysfunction. Chakrabarti S, Syme HM, Brown CA, et al.
Immune-complex glomerulonephritis in cats: a retrospective study based on clinico-pathological data, histopathology and ultrastructural features. Rossi F, Aresu L, Martini V, et al.
5-Aminolevulinic acid with ferrous iron improves early renal damage and hepatic steatosis in high fat diet-induced obese mice. Kamiya, A., Hara, T., Tsuda, M., Tsuru, E., Kuroda, Y, et al

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